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KMID : 0361020240670030171
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Korean Journal of Otolaryngology - Head and Neck Surgery
2024 Volume.67 No. 3 p.171 ~ p.176
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SMARCB1-Deficient Sinonasal Carcinoma?A Case Report and Literature Review
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Kim Tae-Gyeong
Hong Won-Gi
Cho Kyung-Ja
Yu Myeong-Sang
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Abstract
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Switch/sucrose non-fermentable-related matrix-associated actin-dependent regulator of chro-matin subfamily B member 1 (SMARCB1)-deficient sinonasal carcinoma is a rare subtype ofsinonasal undifferentiated carcinoma (SNUC). Due to the highly aggressive nature of the dis-ease course, it is important to diagnose early and use multimodal treatments in the course ofthe disease. Two main morphologic patterns are commonly identified under the microscope:plasmacytoid/rhabdoid and basaloid. Furthermore, it demonstrates a total absence of integraseinteractor 1 expression upon immunohistochemical staining. Here, we present two cases ofSMARCB1-deficient sinonasal carcinoma with contrasting outcomes.
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KEYWORD
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INI-1, sinonasal tumor, Sinonasal undifferentiated carcinoma, SMARCB1-deficient sinonasal carcinoma
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